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Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. [5] LAG3, which was discovered in 1990 [6] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, [7] is a cell surface molecule with diverse biological effects on T cell function but overall has an immune ...
GSK licensed the rights to develop anti-LAG-3 antibodies for autoimmune disease from Immutep in December 2010 in a total deal package worth £64 million. [3] GSK subsequently developed GSK2831781, its own depleting anti-LAG-3 antibody based on IMP731, around 2013 or 2014. GSK's antibody was humanized and was afucosylated for higher ADCC. [4]
Relatlimab is a monoclonal antibody designed for the treatment of melanoma. [3] [4] It is used in combination with nivolumab to treat melanoma. [2] [5] Relatlimab is a Lymphocyte activation gene-3 (LAG-3) inhibitor. [2] [5] It is under development by Bristol-Myers Squibb. [2] [5] It is made using Chinese hamster ovary cells. [2]
IMP731 is a depleting antibody for autoimmune disease that targets LAG3+ activated T cells. GSK licensed the rights to develop such antibodies from Immutep in December 2010 in a total deal package worth £64m. GSK subsequently developed GSK2831781, its own depleting anti-LAG-3 antibody based on Immutep's original IMP731 antibody. [15]
Response rate. At the six-month endpoint, 90% of patients had experienced a clinical benefit. At the six-month endpoint, 90% of patients had experienced a clinical benefit. The overall response rate was 50% based on RECIST criteria, which compared favorably with the 25% response rate observed in patients on paclitaxel monotherapy in the ...
This checkpoint is the target of Merck & Co.'s melanoma drug Keytruda, which gained FDA approval in September 2014. The checkpoint is also the target of EMD Serono (Merck KGaA)'s drug Bavencio, which gained FDA approval in 2017. An advantage of targeting PD-1 is that it can restore immune function in the tumor microenvironment.
Gross margin was 80.8%, an increase of 3.6 percentage points driven by reduced royalty rates for Keytruda and Gardasil, as well as favorable product mix. Operating expenses decreased to $7.4 billion.
Lymphocyte Activation Gene 3 (LAG3), an inhibitory (checkpoint) receptor on immune system T-cells. LAG3 is the target of early-stage drugs for cancer and autoimmune disorders; IMP321 is a soluble version of LAG3, developed by Prima, while BMS-986016 (from Bristol Myers) and GSK2831781 (Glaxo) are anti-LAG3 monoclonal antibodies.
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