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Isosorbide dinitrate is in the nitrate family of medications and works by dilating blood vessels. [1] Isosorbide dinitrate was first written about in 1939. [3] It is on the World Health Organization's List of Essential Medicines. [4] Isosorbide dinitrate is available as a generic medication. [1] [5] A long-acting form exists. [1]
The nitrate esters isosorbide dinitrate (Isordil) and isosorbide mononitrate (Imdur, Ismo, Monoket, Mononitron) are converted in the body to nitric oxide, a potent natural vasodilator. In medicine , these esters are used as a medicine for angina pectoris ( ischemic heart disease ).
By nitration of isosorbide with concentrated nitric acid, 2,5-isosorbide dinitrate (ISDN) can be obtained. 2,5-isosorbide dinitrate is suitable (just like its major metabolite 5-isosorbide mononitrate, ISMN [6]) for the treatment of angina pectoris due to its vasodilator effect. [7]
Nitrates mainly differ in speed and duration of their action. Glyceryl trinitrate acts fast and short (10 to 30 minutes), while most other nitrates have a slower onset of action, but are effective for up to six hours. Molsidomine, as has been mentioned, not only acts slowly but also differs from the nitrates in exhibiting no tolerance. [2]
Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain , heart failure and esophageal spasms. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers . [ 2 ]
Isosorbide dinitrate mixture with not less than 60 percent lactose, mannose, starch or calcium hydrogen phosphate UN 2908: 7: Radioactive material, excepted package ...
In the medical field, nitrate-derived organic esters, such as glyceryl trinitrate, isosorbide dinitrate, and isosorbide mononitrate, are used in the prophylaxis and management of acute coronary syndrome, myocardial infarction, acute pulmonary oedema. [10] This class of drug, to which amyl nitrite also belongs, is known as nitrovasodilators.
The molecular formula C 6 H 9 NO 6 (molar mass: 191.14 g/mol) ... Isosorbide mononitrate; Nitrilotriacetic acid This page was last edited on 8 January 2021, at 05:14 ...
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