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The general stages of seroconversion for hepatitis B, where the line of detectability indicates seropositivity. In immunology, seroconversion is the development of specific antibodies in the blood serum as a result of infection or immunization, including vaccination.
Patients who developed antibodies against HBsAg (anti-HBsAg seroconversion) are usually considered non-infectious. HBsAg detection by immunoassay is used in blood screening, to establish a diagnosis of hepatitis B infection in the clinical setting (in combination with other disease markers) and to monitor antiviral treatment.
Hepatitis B vaccine is a ... but is recommended for infants born to a mother who tests positive for ... As a result, subsequent antibody testing and administration of ...
"Moreover, the finding that one of the participants meeting functional cure criteria had antibodies against hepatitis B is promising as HBsAb positivity is associated with long-term control of the infection by the immune system.” Functional cure is defined by AASLD as sustained HBsAg loss and hepatitis B virus DNA <LLOQ for 6 months off ...
In the case of hepatitis B, blood tests exist for multiple virus antigens (which are different components of the virion particle) and antibodies. [75] The combination of antigen and antibody positivity can provide information about the stage of infection (acute or chronic), the degree of viral replication, and the infectivity of the virus. [75]
The tests, called assays, for detection of hepatitis B virus infection involve serum or blood tests that detect either viral antigens (proteins produced by the virus) or antibodies produced by the host. Interpretation of these assays is complex.
To do this, antibodies that are specific to different types of viruses are mixed with the tissue sample. After the tissue is exposed to a specific wavelength of light or a chemical that allows the antibody to be visualized. [citation needed] These tests require specialized antibodies that are produced and purchased from commercial companies.
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