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An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response.. In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. [1]
Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies (such as insect bites) and asthma. [1] [2] Immunotherapy involves exposing people to larger and larger amounts of allergens in an attempt to change the immune system's response.
Allergen immunotherapy is the last line of medications, also known as the closest "cure" for allergies. It is often recommended for patients whose symptoms cannot be controlled by medications, or those who require multiple medications to control their allergies.
A negative and positive control are also included for comparison (eg, negative is saline or glycerin; positive is histamine). A small plastic or metal device is used to puncture or prick the skin. Sometimes, the allergens are injected "intradermally" into the patient's skin, with a needle and syringe.
In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the allergen cross-links Immunoglobulin E , tyrosine kinases rapidly signal into the cell, leading to cell degranulation and the release of histamine (and other chemical mediators ...
Shellfish allergies are highly cross reactive, but its prevalence is much higher than that of fish allergy. Shellfish allergy is the leading cause of food allergy in U.S adults. [31] As of 2018 six allergens have been identified to prawn alone; along with crab, it is the major culprit of seafood anaphylaxis. [13]
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Food Allergy Research & Education (FARE) is a non-profit, private organization dedicated to food allergy awareness, research, education, and advocacy. FARE's goal is to enhance the lives of people with food allergies by providing support and resources to help them live safe yet productive lives.
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