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The Ireland model In the Ireland model, the deprotonation is assumed to proceed by a six-membered or cyclic [ 19 ] monomeric transition state . The larger of the two substituents on the electrophile (in the case above, methyl is larger than proton) adopts an equatorial disposition in the favored transition state, leading to a preference for E ...
Many factors influence the outcome of enolate stereochemistry, such as steric effects, solvent, polar additives, and types of organolithium bases. Among the many models used to explain and predict the selectivity in stereochemistry of lithium enolates is the Ireland model. [55]
Robert E. Ireland (1929 – February 4, 2012) was an American chemist and the Thomas Jefferson Chair Professor of chemistry at the University of Virginia. He is known for his textbook Organic Synthesis [ 1 ] and his contributions to the Ireland–Claisen rearrangement chemical reaction.
The aldol reaction is paradigmatic in organic chemistry and one of the most common means of forming carbon–carbon bonds in organic chemistry. [5] [6] [7] It lends its name to the family of aldol reactions and similar techniques analyze a whole family of carbonyl α-substitution reactions, as well as the diketone condensations.
The Ireland–Claisen rearrangement is a chemical reaction of an allylic ester with strong base to give an γ,δ-unsaturated carboxylic acid. [1] [2] [3] The Ireland-Claisen rearrangement. Several reviews have been published. [4] [5] [6]
File:Ireland model.svg is a vector version of this file. It should be used in place of this PDF file when not inferior. File:Ireland model enolate.pdf → File: ...
Lithium diisopropylamide (commonly abbreviated LDA) is a chemical compound with the molecular formula LiN(CH(CH 3) 2) 2.It is used as a strong base and has been widely utilized due to its good solubility in non-polar organic solvents and non-nucleophilic nature.
After several years of inactivity, the Irish Chemical Association was formed on 14 March 1936. At the end of the 1940s, it became clear that the association needed to evolve to achieve greater government recognition. A series of meetings led to the formation of the present Institute of Chemistry of Ireland on 18 January 1950. [citation needed]