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Pulsed field ablation (PFA) is a non-thermal (not using extreme heat or cold) method of biological ablation (removal of structure or functionality) utilizing high-amplitude pulsed (microsecond duration) electric fields to create irreversible electroporation in tissues. [1] [2] It is used most widely to treat tumors or cardiac arrhythmias. [3]
Transurethral needle ablation can be used to treat benign prostatic hyperplasia (BPH). [ 4 ] Some clinical studies have reported that TUNA is safe and effective, improving the urine flow with minimal side effects when compared with other procedures, such as transurethral resection of the prostate (TURP) and open prostatectomy .
While thermal radiofrequency ablation for tumors and cardiac arrhythmia has been used for over 25 years, non-thermal pulsed radio frequency is currently being developed for the ablation of cardiac arrhythmias and tumors. The technique uses pulsed radio frequency energy delivered via catheter at frequencies of 300–750 kHz for 30 to 60 seconds ...
Transurethral microwave thermotherapy is a non-surgical, minimally invasive therapy that can be performed under a local anesthetic on an outpatient basis. The treatment involves inserting a special microwave urinary catheter into the hyperplastic prostatic urethra.
Cancer-specific mortality or overall survival are notoriously hard to assess for prostate cancer, as the trials require more than a decade and usually several treatment types are performed during the years making treatment-specific survival advantages difficult to quantify. Therefore, the results of ablation-based treatments and focal ...
Medical applications of radio frequency (RF) energy, in the form of electromagnetic waves (radio waves) or electrical currents, have existed for over 125 years, [1] and now include diathermy, hyperthermy treatment of cancer, electrosurgery scalpels used to cut and cauterize in operations, and radiofrequency ablation. [2]
Studies on localized prostate cancer showed that, after treatment, progression-free survival rates were high for low- and intermediate- risk patients with recurrent prostate cancer. [2] The InsighTec ExAblate 2000 was the first MRgFUS system to obtain FDA market approval, [ 3 ] US patent 5,247,935.
Various local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens to stimulate an immunological response. These ablation therapies can be combined with a systemic immunotherapy: Thermal ablation – local thermal ablation of tumor: Cryoablation; Radiofrequency ablation; High-intensity focused ultrasound ablation
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