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The segment from Columbia to Sumter is a four-lane highway and US 76 is concurrent with US 378 from the intersection of Bull and Gervais near the University of South Carolina in Columbia all the way to Sumter. From Sumter, US 76 heads northeast to Florence. US 76 is the major road through Florence.
U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km). Its western terminus is at US 41 and the eastern terminus of US 72 (Broad Street) in the city of Chattanooga, Tennessee, where it travels in a generally due east direction, to its eastern terminus at Wrightsville Beach, North Carolina.
Third form; northern part of a multi-state highway that also exists in Florida and Georgia SC 122 — — SC 2 in Cayce: US 1 / US 21 / SC 2 / SC 5 / SC 43 / SC 215 in West Columbia: 1942: 1947 First form SC 122: 5.740: 9.238 SC 72 / South Elizabeth Lane in Rock Hill: Waterford Park Drive in Rock Hill: 1975: current Second form SC 123 —
From Columbia, take I-26 West and exit onto I-385 West, according to the Clemson University Athletics Department. From 385, take I-85 South and exit at Exit 40. Make a right on SC Highway 153 ...
US 76 at the North Carolina state line near Nichols: 1926: current Longest US Highway in the state, going east-west; it connects the cities Anderson, Columbia, Sumter, and Florence. US 78: 142.207: 228.860 US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 / SC 121 at the Georgia state line near North Augusta: Line Street in Charleston: 1926
U.S. Route 76 Connector (US 76 Conn.) is a 4.440 mi-long (7.145 km) connector route of US 76 that is an unsigned highway.It exists in three different segments and is located in the west-central part of Richland County and entirely within the city limits of Columbia in the U.S. state of South Carolina.
U.S. Route 176 (US 176) is a spur of US 76 in the U.S. states of North Carolina and South Carolina.The U.S. Highway runs 237.98 miles (382.99 km) from US 25 Business and North Carolina Highway 225 (NC 225) in Hendersonville, North Carolina, east to US 52 in Goose Creek, South Carolina.
U.S. Route 276 Business (Greenville, South Carolina 1940s–1970s) U.S. Route 276 Business (Greenville, South Carolina 1983–1984) U.S. Route 276 Connector (Travelers Rest, South Carolina)