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Genes encoding human Ly6 family members are located in clusters on chromosomes 6, 8, 11 and 19. In the murine genome family members are located on chromosomes 17, 15, 9 and 7, respectively. [ 4 ] [ 3 ] [ 1 ] Genes encoding Ly6 proteins with one LU domain consist of 3 exons and 2 introns .
79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [5] [6] [7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [8]
This gene may also play a role in the pathogenesis of psoriasis vulgaris. [5] The LYNX1 gene codes for a protein (Lynx1) that binds to acetylcholine receptors in the brain. [6] Lynx1 a member of the Ly6 superfamily of proteins that are capable of modulating neurotransmitter receptors. [7]
A duplication of the gene has been detected in a case study of two individuals with severe intellectual disability, suggesting its role in proper brain development and cognitive function. [10] Additionally, the protein demonstrates high expression in several other normal organs including the testis , lungs , stomach , and prostate .
Sca-1 stands for "Stem cells antigen-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. [1] It is the common biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
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Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene. [5] [6] This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. [7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors. [8]
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