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In rare cases, pneumomediastinum may also arise as a result of blunt chest trauma (e.g. car accidents, fights, over pressure of breathing apparatus), while still evolving in the same fashion as the spontaneous form. [13] Pneumomediastinum is most commonly seen in otherwise healthy young male patients and may not be prefaced by a relevant ...
Hamman's syndrome, also known as Macklin's syndrome, is a syndrome of spontaneous subcutaneous emphysema [1] (air in the subcutaneous tissues of the skin) and pneumomediastinum (air in the mediastinum, the center of the chest cavity), sometimes associated with pain and, less commonly, dyspnea (difficulty breathing), dysphonia, and a low-grade fever.
Pneumomediastinum occurs due to the escape of air from ruptured alveoli or airways into the mediastinal space. The rupture of alveoli due to increased intrathoracic pressure (e.g., from coughing, vomiting, or trauma) leads to air tracking along the peribronchovascular interstitium which in turn accumulates in the mediastinum.
Tonofibrils seen under electron microscopy can differentiate thymoma from other tumors such as carcinoid, Hodgkin's, and seminoma. Patients are usually asymptomatic but can present with myasthenia gravis-related symptoms, substernal pain, dyspnea, or cough. Invasive tumors can produce compression effects such as superior vena cava syndrome.
A pneumonectomy is a surgical procedure in which an entire lung is removed. A common reason for performing this procedure is for lung cancer originating in the lung itself. [19] This leads to a mediastinal shift towards the empty side of the thorax. Notably, patients can experience post pneumonectomy syndrome due to a severe mediastinal shift.
Spontaneous pneumothoraces are divided into two types: primary, which occurs in the absence of known lung disease, and secondary, which occurs in someone with underlying lung disease. [17] The cause of primary spontaneous pneumothorax is unknown, but established risk factors include being of the male sex, smoking , and a family history of ...
Chemotherapy for NSCLC usually includes combination of two drugs (chemotherapy doublet), with one of the agents is cisplatin or carboplatin. In 2002, Schiller at al. published in the New England Journal of Medicine, a study that compared four chemotherapy regimens for advanced NSCLC, cisplatin and paclitaxel, cisplatin and gemcitabine, cisplatin and docetaxel, and carboplatin and paclitaxel. [14]
Side effects on the lungs can be very varied, and can include signs and symptoms that are either clinical, or radiological (i.e., seen on chest X-ray or CT), or both.They can include lung inflammation (pneumonitis), secondary (in this context, indirectly caused) lung infection (), lung fibrosis, organising pneumonia (bronchiolitis obliterans organising pneumonia, BOOP), ARDS (acute respiratory ...