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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain . [ 2 ]
Side effects [23] Increased bleeding risk; Rash (Clopidogrel) Dual antiplatelet therapy with aspirin for a reduction of risk of major adverse cardiac events for all acute coronary syndrome patients [24] An image of clopidogrel tablet package (Plavix) Caution. Metabolism of P2Y12 inhibitors requires CYP450 enzymes → potential drug interactions
Nausea is one of the most frequently reported side effects when starting a GLP-1 medication, due to slowed-down digestion. Nausea may be related to overeating while taking these medications as well.
Metabolism of ticlopidine, clopidogrel and prasugrel to an active metabolite. Clopidogrel is a prodrug that is metabolized by two pathways. In one of the pathway most of the dose of clopidogrel (85%) is hydrolyzed by esterases to an inactive carboxylic acid derivate and rapidly cleared via glucoridination followed by renal excretion.
Pfizer announced on Dec. 1 that it was discontinuing phase 3 clinical trials of the twice-daily version due to high rates of adverse side effects. While these were mostly mild, a large percentage ...
Consistently with its reversible mode of action, ticagrelor is known to act faster and shorter than clopidogrel. [35] This means it has to be taken twice instead of once a day which is a disadvantage in respect of compliance, but its effects are more quickly reversible which can be useful before surgery or if side effects occur. [24] [36]
Pfizer said Friday it is halting the testing of a twice-daily obesity drug, citing side effects. The company said in a press release it will now focus its future efforts for the drug, danuglipron ...
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