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The word intron is derived from the term intragenic region, i.e., a region inside a gene. [1] The term intron refers to both the DNA sequence within a gene and the corresponding RNA sequence in RNA transcripts. [2] The non-intron sequences that become joined by this RNA processing to form the mature RNA are called exons. [3]
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA ().It works by removing all the introns (non-coding regions of RNA) and splicing back together exons (coding regions).
Exon trapping or 'gene trapping' is a molecular biology technique that exploits the existence of the intron-exon splicing to find new genes. [13] The first exon of a 'trapped' gene splices into the exon that is contained in the insertional DNA.
When the silencer region is located within an intron, there can be two types of repressions. First, there can be a physical blockage of a splice site. Second, there can be a bend in the DNA that will inhibit RNA processing. [5] When located in the exon or the untranslated region, the silencer will mainly be classical or position-dependent.
Exon trapping is a molecular biology technique to identify potential exons in a fragment of eukaryote DNA of unknown intron-exon structure. [1] This is done to determine if the fragment is part of an expressed gene.
A nested gene is a gene whose entire coding sequence lies within the bounds (between the start codon and the stop codon) of a larger external gene.The coding sequence for a nested gene differs greatly from the coding sequence for its external host gene.
These ribozymes were found in the intron of an RNA transcript, which removed itself from the transcript, as well as in the RNA component of the RNase P complex, which is involved in the maturation of pre-tRNAs. In 1989, Thomas R. Cech and Sidney Altman shared the Nobel Prize in chemistry for their "discovery of catalytic properties of RNA". [7]
In molecular biology, a twintron is an intron-within-intron excised by sequential splicing reactions. A twintron is presumably formed by the insertion of a mobile intron into an existing intron. A twintron is presumably formed by the insertion of a mobile intron into an existing intron.