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After oral or intravenous administration, isavuconazonium is rapidly hydrolysed by esterases in blood or the gastrointestinal tract to the active form, isavuconazole. [7] [8] [15] Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation.
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
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In 2015, the cost of treatment with efinaconazole in the United States was said to be US$2,307 per nail. [ 13 ] In 2019, a study by the Canadian Agency for Drugs and Technologies in Health found the cost for a 48-week course to be $178 for a big toe, and $89 for an other toe.
The cost of living calculator also breaks down the difference in typical costs between the two locations, including average rent and home prices. Let’s say you currently live in Joplin, Missouri ...
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. [5] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. [5]
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. [1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. [2]
Since 2019, wedding costs have grown nearly 20% in the U.K. and 8% in France, but just 2.7% in the U.S. Some have cut their budgets—in Spain, costs are down 1.7%, and in Canada, they're down ...
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