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KS/HH is most often present from birth but adult onset versions are found in both males and females. In those cases, the hypothalamic-pituitary-gonadal axis (HPG axis) functions normally at birth and well into adult life, giving normal puberty and normal reproductive function. The HPG axis then either fails totally or is reduced to a very low ...
Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
Puberty is considered delayed when the child has not begun puberty when two standard deviations or about 95% of children from similar backgrounds have. [7] [8] [9]In North American girls, puberty is considered delayed when breast development has not begun by age 13, when they have not started menstruating by age 15, [2] and when there is no increased growth rate. [8]
[9] [10] [11] Puberty that starts earlier than usual is known as precocious puberty, and puberty which starts later than usual is known as delayed puberty. Notable among the morphologic changes in size, shape, composition, and functioning of the pubertal body, is the development of secondary sex characteristics, the "filling in" of the child's ...
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Precocious puberty on the rise. In the mid-19th century, girls had their first periods — which typically come about two years after they begin to show signs of breasts or pubic hair — at age ...
Starting puberty significantly early — younger than age 8 in girls, 9 in boys — may have health effects lasting into adulthood, including higher risks of breast cancer, diabetes and heart disease.
Research has showed that the average age of starting puberty continues to drop over time: One study published in 2020 shows that the average starting age of puberty for girls has decreased by ...