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Fenofibrate (sold under the brand name Tricor among others), is an oral medication of the fibrate class used to treat abnormal blood lipid levels. [3] It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins.
GLP-1s may be better than other diabetes drugs at helping with liver fat, according to a study published in 2023. Lower Blood Sugar Levels GLP-1s (you may remember) were developed as diabetes meds.
As the liver needs cholesterol to produce bile, the reduced blood cholesterol level causes the liver cells to produce receptors that draw cholesterol from the blood, reducing its level even further. [2] The cholesterol drawn out of the blood in this way is the LDL cholesterol. [2]
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Fibrates decrease the synthesis of bile acid by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and increasing the risk for gallstones.
“The key to preventing liver disease is avoiding things that may be harmful to the liver, including alcohol and unhealthy foods,” says Dr. Allyce Caines, MD, a transplant hepatologist and ...
Fibrates such as fenofibrate or gemfibrozil are considered first-line therapy for the disease. Adjunctive niacin therapy can be used for individuals who are unable to decrease triglyceride levels through fibrate monotherapy. Niacin is especially useful for individuals who have a high risk of getting pancreatitis.
In chronic liver diseases such as cirrhosis, bile acids may deposit in the skin, causing pruritus (itching). Hence, bile acid sequestrants may be used for the prevention of pruritus in patients with chronic liver disease. [10] Bile acid sequestrants may also be used to treat hyperthyroidism as an adjunct therapy.
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