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Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. [1] It is a weak androgen with a potency that is approximately 1/7 that of testosterone. [2] Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT).
Allopregnanolone, a major endogenous inhibitory neurosteroid. Steroid ring system.. This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors.
The neurosteroid ganaxolone, an analog of the progesterone metabolite allopregnanolone, has been extensively investigated in animal models and is currently in clinical trials for the treatment of epilepsy. Neurosteroids, including ganaxolone have a broad spectrum of activity in animal models. [46]
Dehydroepiandrosterone (δ 5-androsten-3β-ol-17-one) – an endogenous androgen, neurosteroid, agonist of PPARα, PXR, and CAR, and testosterone intermediate Androstadienes [ edit ]
[4] [8] [9] However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, [10] and acting as a neurosteroid and modulator of neurotrophic factor receptors. [11] In the United States, DHEA is sold as an over-the-counter supplement, and medication called prasterone.
Adrenal steroids such as glucocorticoids and mineralocorticoids are commonly used as treatments in diseases such as Congenital adrenal hyperplasia. [2] CAH commonly causes overproduction of androgens, glucocorticoid treatment is used to reduce Adrenocorticotropic hormone (ACTH) and reduce the production of androgens allowing for symptoms of CAH to be managed though treatment is required to be ...
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3α-Androstanediol is an inhibitory androstane neurosteroid and weak androgen and estrogen. [1] [2] [3]As a neurosteroid, it acts as a potent positive allosteric modulator of the GABA A receptor, [4] and has been found to have rewarding, [5] [6] anxiolytic, [7] pro-sexual, [8] and anticonvulsant effects.