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Methylprednisolone is commonly prescribed as short-term therapy for acute flares, as seen with acute gouty arthritis. It can be prescribed during on-going therapy in lower doses contingent upon monitorization of adverse effects. [5] Dosage strength and formulation are optimized per medical use. [6]
MCTD has no specific treatment. Management should address the individual's primary issues, such as arthritis, skin disease, or visceral involvement. Low-dose glucocorticoids, nonsteroidal anti-inflammatory medications, hydroxychloroquine, or a combination of these therapies can effectively treat many patients. [65]
Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
For the intramuscular injection, I personally like 40 mg triamcinolone and 20 mg dexamethasone in the same syringe injected into the gluteus. For the oral steroid, I like Prednisone 40 mg every morning for seven days. Prescription will read prednisone 20 mg, two tabs PO Qa.m. x 7d, #14 0RF. 2.
The pain medication paracetamol (acetaminophen) is the first line treatment for osteoarthritis. [61] [95] Pain relief does not differ according to dosage. [62] However, a 2015 review found acetaminophen to have only a small short-term benefit with some concerns on abnormal results for liver function test. [96]
Cymbiotika Ultimate Pain Balm is the best pain relief cream for sensitive skin due to its powerful blend of natural ingredients and ability to provide fast and targeted relief for pain and discomfort.
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