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In molecular biology, an axoneme, also called an axial filament, is the microtubule-based cytoskeletal structure that forms the core of a cilium or flagellum. [ 1 ] [ 2 ] Cilia and flagella are found on many cells , organisms , and microorganisms , to provide motility.
The distal centriole gives rise to the axial filament which forms the tail and has a (9+2) arrangement. A transitory membrane called the Manchette lies in the midpiece. Midpiece It has 10–14 spirals of mitochondria surrounding the axial filament in the cytoplasm. It provides motility, and hence is called the powerhouse of the sperm.
Sperm Spermiogenesis is the final stage of spermatogenesis , during which the spermatids develop into mature spermatozoa . At the beginning of the stage, the spermatid is a more or less circular cell containing a nucleus , Golgi apparatus , centriole and mitochondria ; by the end of the process, it has radically transformed into an elongated ...
A flagellum (/ f l ə ˈ dʒ ɛ l əm /; pl.: flagella) (Latin for 'whip' or 'scourge') is a hair-like appendage that protrudes from certain plant and animal sperm cells, from fungal spores (), and from a wide range of microorganisms to provide motility.
Sperm motility is dependent on several metabolic pathways and regulatory mechanisms. The axonemal bend movement is based on the active sliding of axonemal doublet microtubules by the molecular motor dynein, which is divided into an outer and an inner arm. Outer and inner arm plays different roles in the production and regulation of flagellar motility: the outer arm increase the bea
The spermatids are transformed into spermatozoa (sperm) by the process of spermiogenesis. These develop into mature spermatozoa, also known as sperm cells . [ 2 ] Thus, the primary spermatocyte gives rise to two cells, the secondary spermatocytes, and the two secondary spermatocytes by their subdivision produce four spermatozoa and four haploid ...
Sperm quantity and quality are the main parameters in semen quality, which is a measure of the ability of semen to accomplish fertilization. Thus, in humans, it is a measure of fertility in a man . The genetic quality of sperm, as well as its volume and motility, all typically decrease with age . [ 17 ]
The acrosomal reaction is initiated when sperm comes into contact with the oocyte's zona pellucida. Upon coming into contact with the zona pellucida, the acrosomal enzymes begin to dissolve, and the actin filament comes into contact with the zona pellucida. Once the two meet, a calcium influx occurs, causing a signaling cascade.