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TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
There are a number of reasons for treatment failure. For example, if the infection is a different kind, such as bacterial vaginosis (the most common cause of abnormal vaginal discharge), rather than thrush. [12] Vaginal boric acid has evidence of effectiveness against non-C. albicans species. [28] [29]
Gram stain of cells from the vagina (the same magnification) with normal bacterial flora (top) and the bacteria that cause vaginosis (bottom). A variety of diagnosis techniques are currently available for identifying Gardnerella vaginalis such as the OSOM BV Blue assay, FemExam cards and nucleic acid amplification tests (NAATs), resulting in the determination of ongoing BV.
It may sound simple, but body odor and a sweaty vagina is actually a “super common reason” for vaginal odor, explains Kiarra King, M.D., F.A.C.O.G., board-certified obstetrician and ...
Dweck notes, “This odor is incredibly pungent and worsens with duration of this or other foreign body. It might also suggest infection or rarely, a necrosing genital tumor or growth.”
Boric acid is a weak acid, with pK a (the pH at which buffering is strongest because the free acid and borate ion are in equal concentrations) of 9.24 in pure water at 25 °C. But apparent p K a is substantially lower in swimming pool or ocean waters because of interactions with various other molecules in solution.
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