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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
Parts washers were originally developed for use in automotive transmission and engine repair shops as a way to improve the function of simple soak tanks.Soak tanks are vats filled with a mixture of water and detergent, which take hours to "soften" the built-up road grime, fluids, tars and oils enough to be manually rinsed off prior to disassembly and repair.
Samsung home appliances, such as refrigerators or air conditioners, have a silver nano coating on their inner surfaces for an overall anti-bacterial and anti-fungal effect. As air circulates, the coated surfaces contact with the silver ions which can resist any airborne bacteria, which in turn suppress the respiration of bacteria, adversely ...
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
Samsung is also a major vendor of washing machines, refrigerators, computer monitors and soundbars. [12] Samsung Electronics is a major manufacturer of electronic components such as lithium-ion batteries, semiconductors, image sensors, camera modules, and displays for clients such as Apple, Sony, HTC, and Nokia.
A washer with a "wave" in the axial direction, which provides spring pressure when compressed. Wave washers, of comparable size, do not produce as much force as Belleville washers. In Germany, they are sometimes used as lock washers but they are less effective than other choices. [a] [8] Split washer or spring lock washer
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