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1,3-Propanediol is mainly produced by the hydration of acrolein. An alternative route involves the hydroformylation of ethylene oxide to form 3-hydroxypropionaldehyde. The aldehyde is subsequently hydrogenated to give 1,3-propanediol. Biotechnological routes are also known. [2] Two other routes involve bioprocessing by certain micro-organisms:
Neopentyl glycol (IUPAC name: 2,2-dimethylpropane-1,3-diol) is an organic chemical compound. It is used in the synthesis of polyesters , paints , lubricants , and plasticizers . When used in the manufacture of polyesters, it enhances the stability of the product towards heat, light, and water.
The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2] These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the ...
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects.
Ex 1: The α-keto bromination of propiophenone [93-55-0] (1) gives 2-bromopropiophenone [2114-00-3] (2). Displacement of the halogen and hence amination with piperidine [110-89-4] gave alpha-Piperidinopropiophenone, CID:458526 ( 3 ). and addition of phenyl Grignard reagent to give the benzhydrol product, and hence Dihepanol ( 4 ).
CDPPB is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR 5. [1] [2] [3] It has antipsychotic effects in animal models, [4] and mGluR 5 modulators are under investigation as potential drugs for the treatment of schizophrenia, [5] as well as other applications.
2-Methyl-2-propyl-1,3-propanediol (MPP) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects. Precursor/metabolite
Propanediol may refer to any of four isomeric organic chemical compounds: Non-geminal diols (glycols) 1,2-Propanediol, a.k.a. propylene glycol, a vicinal diol;
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