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Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is a fatal neurodegenerative disease. [ 4 ] [ 1 ] Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. [ 4 ]
Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. [1] Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. [1] [2] [3] He was born in Harburg an der Elbe and died in Munich.
Creutzfeldt may mean: Hans Gerhard Creutzfeldt - German neuropathologist. Otto Detlev Creutzfeldt - German physiologist and neurologist, son of Hans Gerhard Creutzfeldt. Creutzfeldt–Jakob disease - degenerative CNS disorder, named after the authors who first described it.
Magnified 100X, and stained with H&E (hematoxylin and eosin) staining technique, this light photomicrograph of brain tissue reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (vCJD). Variant Creutzfeldt-Jakob disease (vCJD) is a prion disease that was first ...
Electroencephalogram (EEG) is used to distinguish kuru from Creutzfeldt–Jakob disease, a similar encephalopathy (any disease that affects the structure of the brain). [28] EEGs search for electrical activity in the person's brain and measure the frequency of each wave to determine if there is an issue with the brain's activity. [29]
He coined the term "Creutzfeldt–Jakob disease" to refer to a rapidly progressive neurodegenerative disease first described separately by the eponymous German neurologists. [ 4 ] Walther Spielmeyer and his laboratory team at Munich, 1927 (Spielmeyer at center front).
This was confirmed with the identification of a Kuru-like disease, called new variant Creutzfeldt–Jakob disease, in humans exposed to BSE. [50] Although the infectious disease model of TSE has been questioned in favour of a prion transplantation model that explains why cannibalism favours transmission, [ 51 ] the search for a viral agent was ...
Variant Creutzfeldt–Jakob disease (vCJD), formerly known as New variant Creutzfeldt–Jakob disease (nvCJD) and referred to colloquially as "mad cow disease" or "human mad cow disease" to distinguish it from its BSE counterpart, is a fatal type of brain disease within the transmissible spongiform encephalopathy family. [7]