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Spironolactone may be more effective than birth control pills in the treatment of acne, and the combination of spironolactone with a birth control pill may have greater effectiveness for acne than either alone. [85] In addition, some clinical research has found that flutamide is more effective than spironolactone in the treatment of acne. [64]
According to a study in JAMA Dermatology, the prescribing rates of spironolactone for acne in women rose about 300% from 2017 to 2020.
Isotretinoin (an anti-acne drug that can cause an initial purge) ... Spironolactone: Spironolactone is used to treat high blood pressure but is also prescribed off-label for treating acne in women.
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women. [1] Metformin also causes off-target activity. [citation needed]
Spironolactone blocks your sensitive receptors from your androgens (aka the "male" sex hormones), which helps reduce oil and acne. It's a once-a-day treatment that's typically super effective ...
Side effects often could not be unambiguously attributed to spironolactone due concomitant use of other medications, particularly birth control pills. Hyperkalemia was rare (14/469; 3.0%) and was "invariably mild and clinically insignificant". Risk of bias was high and quality of evidence was low to very low. Sources: [1]
There are also several oral contraceptives that are also FDA-approved to treat hormonal acne and are sometimes prescribed in conjunction with spironolactone. They work by regulating your hormones ...