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  2. P-site - Wikipedia

    en.wikipedia.org/wiki/P-site

    The ribosomal P-site plays a vital role in all phases of translation. Initiation involves recognition of the start codon (AUG) by initiator tRNA in the P-site, elongation involves passage of many elongator tRNAs through the P site, termination involves hydrolysis of the mature polypeptide from tRNA bound to the P-site, and ribosome recycling involves release of deacylated tRNA.

  3. E-site - Wikipedia

    en.wikipedia.org/wiki/E-site

    The E-site is the third and final binding site for t-RNA in the ribosome during translation, a part of protein synthesis. [1] The "E" stands for exit, and is accompanied by the P-site (for peptidyl) which is the second binding site, and the A-site (aminoacyl), which is the first binding site. It is involved in cellular processes. [2]

  4. Translation (biology) - Wikipedia

    en.wikipedia.org/wiki/Translation_(biology)

    The P/E-site holds the tRNA with the growing polypeptide chain. When an aminoacyl-tRNA initially binds to its corresponding codon on the mRNA, it is in the A site. Then, a peptide bond forms between the amino acid of the tRNA in the A site and the amino acid of the charged tRNA in the P/E site. The growing polypeptide chain is transferred to ...

  5. Bacterial translation - Wikipedia

    en.wikipedia.org/wiki/Bacterial_translation

    The A site is the point of entry for the aminoacyl tRNA (except for the first aminoacyl tRNA, which enters at the P site). The P site is where the peptidyl tRNA is formed in the ribosome. And the E site which is the exit site of the now uncharged tRNA after it gives its amino acid to the growing peptide chain. [1]

  6. Eukaryotic translation - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_translation

    The Met-charged initiator tRNA (Met-tRNA i Met) is brought to the P-site of the small ribosomal subunit by eukaryotic initiation factor 2 (eIF2). It hydrolyzes GTP, and signals for the dissociation of several factors from the small ribosomal subunit, eventually leading to the association of the large subunit (or the 60S subunit).

  7. Ribosome - Wikipedia

    en.wikipedia.org/wiki/Ribosome

    Affinity label for the tRNA binding sites on the E. coli ribosome allowed the identification of A and P site proteins most likely associated with the peptidyltransferase activity; [5] labelled proteins are L27, L14, L15, L16, L2; at least L27 is located at the donor site, as shown by E. Collatz and A.P. Czernilofsky.

  8. A-site - Wikipedia

    en.wikipedia.org/wiki/A-site

    The A-site (A for aminoacyl) of a ribosome is a binding site for charged t-RNA molecules during protein synthesis. [1] One of three such binding sites, the A-site is the first location the t-RNA binds during the protein synthesis process, the other two sites being P-site (peptidyl) and E-site (exit).

  9. Transfer RNA - Wikipedia

    en.wikipedia.org/wiki/Transfer_RNA

    The tRNA bound in the E/E site then leaves the ribosome. The P/I site is actually the first to bind to aminoacyl tRNA, which is delivered by an initiation factor called IF2 in bacteria. [26] However, the existence of the P/I site in eukaryotic or archaeal ribosomes has not yet been confirmed. The P-site protein L27 has been determined by ...

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