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Fick's first law relates the diffusive flux to the gradient of the concentration. It postulates that the flux goes from regions of high concentration to regions of low concentration, with a magnitude that is proportional to the concentration gradient (spatial derivative), or in simplistic terms the concept that a solute will move from a region of high concentration to a region of low ...
The grey represents the concentration of a molecule. A biomolecular gradient is established by a difference in the concentration of molecules in a biological system such as individual cells, groups of cells, or an entire organism. A biomolecular gradient can exist intracellularly (within a cell) or extracellularly (between groups of cells).
In the phenomenological approach, diffusion is the movement of a substance from a region of high concentration to a region of low concentration without bulk motion. According to Fick's laws, the diffusion flux is proportional to the negative gradient of concentrations. It goes from regions of higher concentration to regions of lower concentration.
Donnan equilibrium across a cell membrane (schematic). The Gibbs–Donnan effect (also known as the Donnan's effect, Donnan law, Donnan equilibrium, or Gibbs–Donnan equilibrium) is a name for the behaviour of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane. [1]
Facilitated diffusion in cell membrane, showing ion channels and carrier proteins. Facilitated diffusion (also known as facilitated transport or passive-mediated transport) is the process of spontaneous passive transport (as opposed to active transport) of molecules or ions across a biological membrane via specific transmembrane integral proteins. [1]
is the gradient, i.e., rate of change with position, of the logarithm of the salt concentration, which is equivalent to the rate of change of the salt concentration, divided by the salt concentration – it is effectively one over the distance over which the concentration decreases by a factor of e. The above equation is approximate, and ...
Before this point in time, a gradual variation in the concentration of A occurs along an axis, designated x, which joins the original compartments. This variation, expressed mathematically as -dC A /dx, where C A is the concentration of A. The negative sign arises because the concentration of A decreases as the distance x increases.
The horizontal axis is the concentration of the ligand. As the Hill coefficient is increased, the saturation curve becomes steeper. In biochemistry and pharmacology , the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration .