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Another test is specific for DNA from HPV types 16 and 18, the two types that cause most HPV-associated cancers. A third test can detect DNA from several high-risk HPV types and can indicate whether HPV-16 or HPV-18 is present. A fourth test detects RNA from the most common high-risk HPV types.
“We are highlighting that HPV screening, as the primary screening for women ages 30 to 65, is the best balance between the benefits and the harms in finding cervical cancer, and that should be ...
Some people can have elevated levels of p16 but test negative for HPV and vice versa. This is known as discordant cancer. The 5-year survival for people who test positive for HPV and p16 is 81%, for discordant cancer it is 53 – 55%, and 40% for those who test negative for p16 and HPV. [208] [209]
In England, the NHS cervical screening programme is available to women aged 25 to 64; women aged 25 to 49 receive an invitation every 3 years and women aged 50 to 64 receive an invitation every 5 years to undergo HPV testing. [15] [16] If there is a positive HPV test result, then patients undergo further cytology (Pap smear). [15]
Medicare Part B covers the costs of HPV testing. It provides coverage once every 5 years for people between the ages of 30 and 65 years without HPV symptoms.The HPV test is part of the Pap test ...
The FDA has given the green light to a self-collection solution to test for HPV, making it one of the easiest options available in the U.S. for identifying those at risk of cervical cancer.
This includes cervical cytology every 3 years, HPV testing every 5 years, or HPV testing together with cytology every 5 years. [88] [86] Screening is not beneficial before age 25, as the rate of disease is low. Screening is not beneficial in women older than 60 years if they have a history of negative results. [52]
However, some people can have elevated levels of p16 but test negative for HPV and vice versa. This is known as discordant cancer. The 5-year survival for people who test positive for HPV and p16 is 81%, for discordant cancer it is 53–55%, and 40% for those who test negative for p16 and HPV. [33] [34]