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Nifedipine, sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. [2] It is one of the treatments of choice for Prinzmetal angina. [2] It may be used to treat severe high blood pressure in pregnancy. [2]
Nifedipine (Procardia, Adalat) Ca 2+ channel blocker: Is one of the most commonly used tocolytic agents. [25] Hypotension, preload-dependent cardiac disease. [26] It should not be used concomitantly with magnesium sulfate [27] Flushing, headache, dizziness, nausea, transient hypotension. Administration of calcium channel blockers should be used ...
Slowing down the conduction of electrical activity within the heart, by blocking the calcium channel during the plateau phase of the action potential of the heart (see: cardiac action potential), results in a negative chronotropic effect, or a lowering of heart rate. This can increase the potential for heart block.
Thus, it prolongs QT interval of action potential and increases the risk of torsade de pointes. [ 1 ] Procainamide could initiate leukopenia and/or agranulocytosis , which are serious hematologic disorders, and is also known for causing gastrointestinal disturbances and aggravating pre-existing abnormalities in impulse initiation and propagation.
The exact mechanism of action of nitrendipine is unknown, but it is believed to have important tyrosine and threonine residues in its binding pocket and its binding interferes with the voltage sensor and gating mechanism of the channel. [4] Thought to have a domain-interface model of binding.
Spoilers ahead! We've warned you. We mean it. Read no further until you really want some clues or you've completely given up and want the answers ASAP. Get ready for all of today's NYT ...
Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridine calcium channel blockers (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. It is primarily a peripheral arterial vasodilator, thus unlike the nitrovasodilators (nitroglycerin ...
Usual onset: Within 6 hours [2] Causes: Too much calcium channel blockers either by accident or on purpose [3] Differential diagnosis: Beta blocker toxicity [1] Treatment: Activated charcoal, whole bowel irrigation, intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors, lipid emulsion [1] [2] Prognosis: High risk of ...