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XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.
For avoiding pregnancy, the perfect-use failure rate of Creighton was 0.5%, which means that for each year that 1,000 couples using this method perfectly, that there are 5 unintended pregnancies. The typical-use failure rate, representing the fraction of couples using this method that actually had an unintended pregnancy, is reported as 3.2% ...
Typically, women with Müllerian abnormalities have a normal female karyotype (46, XX). Most incidences of Müllerian anomalies occur sporadically, with instances of familial inheritance patterns being less common. [30] The genetic component of the disease classically follows an autosomal dominant pattern, with variable rates of genotypic ...
1 in 4,500 females [1] Müllerian agenesis , also known as Müllerian aplasia , vaginal agenesis , or Mayer–Rokitansky–Küster–Hauser syndrome ( MRKH syndrome ), is a congenital malformation characterized by a failure of the Müllerian ducts to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper ...
An estimated 3 million pregnant women in the USA were prescribed DES from 1941 through 1971. [2] [3] DES was also widely prescribed to women in Canada, the UK, Europe, Australia, and New Zealand during a similar period. Women who were prescribed DES during pregnancy have been shown to have a modestly increased risk of breast cancer and breast ...
Women are 4-5 times more likely to develop a clot during pregnancy and in the postpartum period than when they are not pregnant. [25] Hypercoagulability in pregnancy likely evolved to protect women from hemorrhage at the time of miscarriage or childbirth. In developing countries, the leading cause of maternal death is still hemorrhage. [25]
Streak gonads are a form of aplasia, resulting in hormonal failure that manifests as sexual infantism and infertility, with no initiation of puberty and secondary sex characteristics. [ 4 ] Gonadal development is a process, which is primarily controlled genetically by the chromosomal sex ( XX or XY ), which directs the formation of the gonad ...
It is most problematic in genetic females, where severe virilization can result in funding of labia and an enlarged clitoris. [34] [35] Females with this condition are usually fertile, with the ability to become pregnant and give birth. The salt-wasting variety of this condition is fatal in infants if left untreated.