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Static encephalopathy: Unchanging, or permanent, brain damage, usually caused by prenatal exposure to ethanol. Uremic encephalopathy: Arising from high levels of toxins normally cleared by the kidneys—rare where dialysis is readily available. Wernicke's encephalopathy: Arising from thiamine (B 1) deficiency, usually in the setting of alcoholism.
Ashley was born with a severe brain impairment of genetic cause, [2] termed a "static encephalopathy" because it does not improve.Although she sleeps and awakens, and breathes on her own, she is unable to raise her head, sit up, hold an object, walk, or talk, and must be tube-fed.
Sepsis-associated encephalopathy (SAE), also known as sepsis-associated brain dysfunction or septic encephalopathy, is a type of infectious disease-associated encephalopathy (IDAE).
The term "infectious disease-associated encephalopathy" was first coined in 2021 and this was also when the first literature review of the overarching concept was published. [1] [2] The term "sepsis-associated encephalopathy" was first used by 1990 and this was when the first comprehensive study of this condition was published. [7] [4]
Fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorder, static encephalopathy, alcohol-related birth defects [1] Causes: Drinking alcohol during pregnancy [1] Diagnostic method: Based on symptoms and prenatal alcohol exposure [1] Differential diagnosis
Degenerative spinal disorders involve a loss of function in the spine. Pressure on the spinal cord and nerves may be associated with herniation or disc displacement. Brain degeneration also causes central nervous system diseases (i.e. Alzheimer's, Lewy body dementia, Parkinson's, and Huntington's diseases).
A name for the disease before the gene was identified was called static encephalopathy of childhood with neurodegeneration in adulthood (SENDA), though this term is no longer used. BPAN typically causes developmental delay and epilepsy from early childhood. An unusual feature experienced by many is a tendency to overeat without feeling full.
The symptoms variably include feelings of increased self-awareness, mental clarity, certainty, feelings of "unity with everything that exists" (including the external environment), intense positive affect, a sense of intense serenity or bliss, mystical, spiritual, or religious experiences, physical well-being, a sense of "hyper-reality", and time dilation, among others.