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Alpha-1 blocker, blocks alpha receptors and it relaxes the smooth muscles in the bladder. It helps the urine to flow smoothly and it can lessen the pain caused by the bladder pressing on the prostate. [44] [45] Selective alpha-1 blockers are better tolerated than non-selective alpha blockers in the body and therefore works better on BPH. [2]
When the term "alpha blocker" is used without further qualification, it can refer to an α 1 blocker, an α 2 blocker, a nonselective blocker (both α 1 and α 2 activity), or an α blocker with some β activity. [2] However, the most common type of alpha blocker is usually an α 1 blocker. Non-selective α-adrenergic receptor antagonists include:
Mechanism of Action of Alpha -1 blocker. Alpha 1 blocker exerts its action on alpha-1 receptor, dilating the smooth muscles. [3] Alpha-1 receptor is a Gq type G-protein coupled receptor. [3] When it is activated, it will lead to activation of phospholipase C, raising the intracellular level of IP3 and DAG. [3]
Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. [10] Specifically it is an α 1-adrenergic receptor blocker. [6] Tamsulosin was approved for medical use in the United States in 1997. [6] It is available as a generic medication. [9]
Prazosin is an α 1-blocker that acts as a non-selective inverse agonist at α 1-adrenergic receptors, including of the α 1A-, α 1B-, and α 1D-adrenergic receptor subtypes. [24] It binds to these receptors with affinity (K i ) values of 0.13 to 1.0 nM for the α 1Α -adrenergic receptor, 0.06 to 0.62 nM for the α 1B -adrenergic receptor ...
They work by inhibiting the synthesis, release, or reuptake of the neurotransmitters or by antagonising the receptors on postsynaptic neurones. Their medical uses, mechanisms of action, adverse effects, and contraindications depend on the specific types of adrenergic blockers used, including alpha 1, alpha 2, beta 1, and beta 2.
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Alfuzosin, sold under the brand name Uroxatral among others, is a medication of the α 1 blocker class. It is used to treat benign prostatic hyperplasia (BPH). [1]As an antagonist of the α 1-adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making urination easier.