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The linear no-threshold model (LNT) is a dose-response model used in radiation protection to estimate stochastic health effects such as radiation-induced cancer, genetic mutations and teratogenic effects on the human body due to exposure to ionizing radiation. The model assumes a linear relationship between dose and health effects, even for ...
Low-threshold treatment programs are harm reduction-based health care centers targeted towards people who use substances. [1] "Low-threshold" programs are programs that make minimal demands on the patient, offering services without attempting to control their intake of drugs, and providing counselling only if requested.
The liability-threshold model is frequently employed in medicine and genetics to model risk factors contributing to disease. In a genetic context, the variables are all the genes and different environmental conditions, which protect against or increase the risk of a disease, and the threshold z is the biological limit past which disease ...
Risk assessment determines possible mishaps, their likelihood and consequences, and the tolerances for such events. [1] [2] The results of this process may be expressed in a quantitative or qualitative fashion. Risk assessment is an inherent part of a broader risk management strategy to help reduce any potential risk-related consequences. [1] [3]
Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. [1] Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study.
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For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.
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