Search results
Results from the WOW.Com Content Network
Induced pluripotent stem cells are similar to natural pluripotent stem cells, such as embryonic stem cells, in many aspects, such as the expression of certain stem cell genes and proteins, chromatin methylation patterns, doubling time, embryoid body formation, teratoma formation, viable chimera formation, and potency and differentiability, but ...
A stem cell line is a group of stem cells that is cultured in vitro and can be propagated indefinitely. Stem cell lines are derived from either animal or human tissues and come from one of three sources: embryonic stem cells, adult stem cells, or induced pluripotent stem cells. They are commonly used in research and regenerative medicine.
Several studies suggest a role for Oct-4 in sustaining self-renewal capacity of adult somatic stem cells (i.e. stem cells from epithelium, bone marrow, liver, etc.). [31] Other scientists have produced evidence to the contrary, [ 32 ] and dismiss those studies as artifacts of in vitro culture, or interpreting background noise as signal, [ 33 ...
Using genetic reprogramming with protein transcription factors, pluripotent stem cells with ESC-like capabilities have been derived. [73] [74] [75] The first demonstration of induced pluripotent stem cells was conducted by Shinya Yamanaka and his colleagues at Kyoto University. [76]
Pluripotent is also described as something that has no fixed developmental potential, as in being able to differentiate into different cell types in the case of pluripotent stem cells. [1] One type of pluripotent cell, called a hematopoietic stem cell, can differentiate into a large variety of cells with different functions. This stem cell can ...
Induced pluripotency is possible using adult neural stem cells, which express higher levels of Sox2 and c-Myc than embryonic stem cells. Therefore, only two exogenous factors, one of which is necessarily Oct4, are sufficient for inducing pluripotent cells from neural stem cells, lessening the complications and risks associated with introducing ...
These include embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) EBs are differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers. They mimic the characteristics seen in early-stage embryos. They are often used as a model system to conduct research on various aspects of ...
James Alexander Thomson is an American developmental biologist best known for deriving the first human embryonic stem cell line in 1998 [1] and for deriving human induced pluripotent stem cells (iPS) in 2007. [2]