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The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-octanol and water. [1] K ow is also frequently referred to by the symbol P, especially in the English literature. It is also called n-octanol-water partition ratio. [2] [3] [4]
The partition coefficient between n-Octanol and water is known as the n-octanol-water partition coefficient, or K ow. [62] It is also frequently referred to by the symbol P, especially in the English literature. It is also known as n-octanol-water partition ratio. [63] [64] [65]
Coefficients for partition between water and solvents wet/dry solvent c e s a b v source w 1-butanol: 0.376 0.434 -0.718 -0.097 -2.350 2.682 [1]w
Bioconcentration factors can also be related to the octanol-water partition coefficient, K ow. The octanol-water partition coefficient (K ow) is correlated with the potential for a chemical to bioaccumulate in organisms; the BCF can be predicted from log K ow, via computer programs based on structure activity relationship (SAR) [7] or through ...
Octanol-water partition coefficients Critical data The mixture data banks contain (as of April 2007 [update] ) approx. 308,000 data sets with 2,157,000 data points for 10,750 components building 84,870 different binary, ternary, and higher systems/combinations.
For nonionic organic contaminants, the K OC can be determined based on the octanol-water partition coefficient (K OW). C OC is the organic carbon normalized sediment concentration (micrograms per kilogram OC) and C d is the dissolved interstitial water concentration (milligrams per liter). The equation above can be rearranged to: C OC = K OC C d.
The ratio gives the relative hydrophobicity scale for individual amino acids. Computation was trained on high resolution protein crystal structures. This quantitative descriptor for microenvironment was derived from the octanol-water partition coefficient, (known as Rekker's Fragmental Constants) widely used for pharmacophores. This scale well ...
The distribution coefficient (K c which coincides with partition coefficient) of atabrine varied by the composition of the solvent system and the pH of the buffer. In the next article, Craig was inspired by the work of Martin and Synge with partition chromatography to develop an apparatus that would separate compounds based on their ...