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Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is ...
Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [ 33 ] [ 34 ] [ 35 ] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells.
The diagnosis of Alzheimer's disease typically requires a microscopic analysis of plaques and tangles in brain tissue, usually at autopsy. [40] However, Aβ plaques (along with cerebral Aβ-amyloid angiopathy ) can be detected in the brains of living subjects by preparing radiolabeled agents that bind selectively to Aβ deposits in the brain ...
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...
The exact cause of Alzheimer’s disease has long evaded scientists, but experts typically suggest there are likely several factors (like genetics, environment, and lifestyle) that contribute to ...
The ion channel hypothesis of Alzheimer's disease (AD), also known as the channel hypothesis or the amyloid beta ion channel hypothesis, is a more recent variant of the amyloid hypothesis of AD, which identifies amyloid beta (Aβ) as the underlying cause of neurotoxicity seen in AD. [1]
Dementia directly affects more than 55 million people worldwide, and up to 70% of those people have Alzheimer’s disease, which is characterized by a loss of brain cells associated with the toxic ...
The paper, "A specific amyloid-β protein assembly in the brain impairs memory", suggested the Aβ*56 oligomer (known as amyloid beta star 56 and Abeta*56) [15] as a cause of Alzheimer's disease. [ 12 ] [ 23 ] The study proposed that Aβ*56 was responsible for the memory deficits that occur in Alzheimer's. [ 22 ]
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