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  2. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [ 33 ] [ 34 ] [ 35 ] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells.

  3. New study challenges amyloid-beta theory on cause for ... - AOL

    www.aol.com/study-challenges-amyloid-beta-theory...

    A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...

  4. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is ...

  5. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    [22] [39] Although the number of neurofibrillary tangles correlates more strongly with the degree of dementia than does the number of plaques, genetic and pathological findings indicate that Aβ plays a central role in the risk, onset, and progression of Alzheimer's disease. [21] The diagnosis of Alzheimer's disease typically requires a ...

  6. Shifts in brain activity may signal Alzheimer's long before ...

    www.aol.com/shifts-brain-activity-may-signal...

    Scientists have spotted changes in brain activity that may point to Alzheimer’s. RapidEye/Getty Images ... the cause of Alzheimer’s disease includes the build-up of amyloid-beta and tau ...

  7. Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Alzheimer's_disease

    The causes of Alzheimer's disease remain poorly understood. [16] There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. [17] [18] Other risk factors include a history of head injury, clinical depression, and high blood pressure. [1]

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