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In a cord blood transplant, stems cells are collected from umbilical cord blood. Umbilical cord blood is the blood left in the umbilical cord after a baby's birth. The cord blood can be frozen and stored until it's used in a cord blood transplant.
Nearly 400 adults and children have received umbilical cord blood transplants at MSK. These transplants offer the best chance of a cure for blood cancer in patients who are unable to find a matched donor, often due to their non-European ancestry. Learn more.
Donated cord blood is tested, frozen and stored at a blood bank for future use. Cord blood stem cell transplantation, including transplants with two or more cord blood units, is an established practice. Research studies are testing ways in which more cord blood cells can be grown in the laboratory.
Hematopoietic cell transplants using stem cells from umbilical cord blood are used worldwide for the treatment of malignant and non-malignant disorders. Transplant procedures from this stem cell source have shown promising outcomes in successfully treating various hematologic, immunologic, malignant, and inherited metabolic disorders.
Another type of allogeneic transplant uses stem cells from the blood of umbilical cords (cord blood transplant). Mothers can choose to donate umbilical cords after their babies' births. The blood from these cords is frozen and stored in a cord blood bank until needed for a bone marrow transplant.
Researchers supported by NIDDK have discovered key factors that promote blood stem cell growth and maturation, and, with these insights, have developed ways to expand the numbers of cells from cord blood for use in transplants.
Cord blood stem cell transplants carry less risk of transmission of blood-borne infectious diseases compared with stem cells from the peripheral blood or marrow of related or unrelated donors.
Cord blood could be a suitable stem cell transplant option if you: have a condition that means that you’re not able to make your own healthy blood cells – for example, aplastic anaemia or a genetic condition affecting your blood, bone marrow or immune system; have a type of blood cancer that chemotherapy might not cure alone
For people who don’t have a matched bone marrow or stem cell donor, a cord blood transplant may offer the best chance for being cured of blood cancer. Allogeneic stem cell or bone marrow transplants can be lifesavers for people with a blood cancer such as leukemia or lymphoma.
A bone marrow transplant or umbilical cord blood transplant (also called BMT) replaces diseased blood-forming cells (also called blood stem cells) with healthy cells. Diseases Treatable with a Bone Marrow Transplant or Cord Blood Transplant