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Calorie restriction (also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. [ 1 ][ 2 ] The possible effect of calorie restriction on body weight management, longevity, and aging-associated diseases has been an active area of research.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [ 1 ] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [ 2 ] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Cellular senescence is a phenomenon characterized by the cessation of cell division. [ 1 ][ 2 ][ 3 ] In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. [ 4 ][ 5 ][ 6 ] This ...
These findings were independent, in that more sugar meant more accelerated biological age, even if a woman's overall diet was healthier, but sticking to a healthier overall diet was associated ...
These lifestyle factors may support cellular health by preventing methylation, which can influence gene expression. Experts say the best way to adopt Life’s Essential 8 behaviors is by taking ...
The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 [1] to conceptualize the essence of biological aging and its underlying ...
PARIS — With the aim of reversing cellular aging, Parfums Christian Dior has entered into a research collaboration with Vadim N. Gladyshev, a professor of medicine at Brigham and Women’s ...
The term "engineered negligible senescence" first appeared in print in Aubrey de Grey's 1999 book The Mitochondrial Free Radical Theory of Aging. [8] De Grey defined SENS as a "goal-directed rather than curiosity-driven" [ 9 ] approach to the science of aging, and "an effort to expand regenerative medicine into the territory of aging".