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Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. [ 5 ] In the 1950s IGF-1 was called " sulfation factor" because it stimulated sulfation of cartilage in vitro, [ 6 ] and in the 1970s due ...
These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things. [8] The physiological importance for cell senescence has been attributed to prevention of carcinogenesis, and more recently, aging, development, and tissue repair. [9]
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1 ...
Aging-associated diseases. An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age (with rare exceptions) but not ...
Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal growth. Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways.
Pulmonary function testing is a diagnostic and management tool used for a variety of reasons, such as: Diagnose lung disease. Monitor the effect of chronic diseases like asthma, chronic obstructive lung disease, or cystic fibrosis. Detect early changes in lung function. Identify narrowing in the airways.
Growth hormone (GH) or somatotropin, also known as human growth hormone (h. HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of insulin-like growth factor 1 (IGF-1) and increases the ...
Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. [ 5 ][ 6 ] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor ...