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Oxygen saturation is the fraction of oxygen -saturated haemoglobin relative to total haemoglobin (unsaturated + saturated) in the blood. The human body requires and regulates a very precise and specific balance of oxygen in the blood. Normal arterial blood oxygen saturation levels in humans are 96–100 percent. [ 1 ]
Hypoxemia refers to insufficient oxygen in the blood. Thus any cause that influences the rate or volume of air entering the lungs (ventilation) or any cause that influences the transfer of air from the lungs to the blood may cause hypoxemia. As well as these respiratory causes, cardiovascularcauses such as shuntsmay also result in hypoxemia.
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. [ 1 ] Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. [ 2 ] Although hypoxia is often a pathological condition, variations in arterial oxygen ...
Hemoglobin has an oxygen-binding capacity of 1.34 mL of O 2 per gram, [6] which increases the total blood oxygen capacity seventy-fold compared to dissolved oxygen in blood plasma alone. [7] The mammalian hemoglobin molecule can bind and transport up to four oxygen molecules. [8] Hemoglobin also transports other gases.
In its simplest form, the oxyhemoglobin dissociation curve describes the relation between the partial pressure of oxygen (x axis) and the oxygen saturation (y axis). Hemoglobin's affinity for oxygen increases as successive molecules of oxygen bind. More molecules bind as the oxygen partial pressure increases until the maximum amount that can be ...
Signs and symptoms. In individuals with chronic obstructive pulmonary disease and similar lung problems, the clinical features of oxygen toxicity are due to high carbon dioxide content in the blood (hypercapnia). [1] This leads to drowsiness (narcosis), deranged acid-base balance due to respiratory acidosis, and death.
Blood gas tension refers to the partial pressure of gases in blood. [1] There are several significant purposes for measuring gas tension. [2] The most common gas tensions measured are oxygen tension (P x O 2), carbon dioxide tension (P x CO 2) and carbon monoxide tension (P x CO). [3] The subscript x in each symbol represents the source of the ...
The Haldane effect is a property of hemoglobin first described by John Scott Haldane, within which oxygenation of blood in the lungs displaces carbon dioxide from hemoglobin, increasing the removal of carbon dioxide. Consequently, oxygenated blood has a reduced affinity for carbon dioxide. Thus, the Haldane effect describes the ability of ...
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