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  2. Brushfield spots - Wikipedia

    en.wikipedia.org/wiki/Brushfield_spots

    Brushfield spots tend to be obscured by pigmentation of the anterior border layer of the iris in patients with darker irides. Hence, they are much more likely to be observed in children with lightly pigmented eyes. Brushfield spots are more commonly found in Down syndrome patients of European descent than similarly affected children of Asian ...

  3. Down syndrome - Wikipedia

    en.wikipedia.org/wiki/Down_syndrome

    Down syndrome or Down's syndrome, [12] also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. [3] It is usually associated with developmental delays, mild to moderate intellectual disability , and characteristic physical features.

  4. Everything you need to know about Down syndrome - AOL

    www.aol.com/news/everything-know-down-syndrome...

    According to the Centers for Disease Control, each year about 6,000 babies are born with Down syndrome, making it the most common chromosomal disorder. That's about 1 in every 700 newborns. That's ...

  5. Palpebral fissure - Wikipedia

    en.wikipedia.org/wiki/Palpebral_fissure

    It can be reduced (short, "narrow") in horizontal size by fetal alcohol syndrome [1] and in Williams syndrome.The chromosomal conditions trisomy 9 and trisomy 21 (Down syndrome) can cause the palpebral fissures to be upslanted, [2] whereas Marfan syndrome can cause a downslant. [3]

  6. Hypertelorism - Wikipedia

    en.wikipedia.org/wiki/Hypertelorism

    Hypertelorism is an abnormally increased distance between two organs or bodily parts, usually referring to an increased distance between the orbits (eyes), or orbital hypertelorism. In this condition the distance between the inner eye corners as well as the distance between the pupils is greater than normal.

  7. Low-set ears - Wikipedia

    en.wikipedia.org/wiki/Low-set_ears

    Clinically, if the point at which the helix (curved upper part) of the outer ear meets the cranium is at or below the line connecting the inner canthi of eyes (the bicanthal plane), the ears are considered low set. [2] [1] Low-set ears can be associated with conditions such as: Down syndrome [3] Turner syndrome; Noonan syndrome [4] Patau ...

  8. A mom of 3 learned she had mosaic Down syndrome through ... - AOL

    www.aol.com/lifestyle/mom-3-learned-she-had...

    Sonja Rasmussen, M.D., professor of genetic medicine at the Johns Hopkins University School of Medicine, explains how Down syndrome and mosaic Down syndrome differ. “Typically, we all have 46 ...

  9. Cyclopia - Wikipedia

    en.wikipedia.org/wiki/Cyclopia

    Cyclopia (named after the Greek mythology characters cyclopes), also known as alobar holoprosencephaly, is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities.