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Increase in systemic exposure is proportional over the dose range of 50–400 mg. No time-dependent change in kinetics was observed through 12 weeks of dosing. Apparent steady state for armodafinil was reached within 7 days of dosing. At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose.
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A dosage of up to 200–250 mg daily for a sustained period of six to twelve months may be needed to cure hyperacusis. A possible mechanism of action of this drug is that clomipramine reduces reactions of the autonomic nervous system to sounds. [53] The drug ambroxol helps relieve the pain experienced by several pain hyperacusis patients.
Since 2020, Duearity has been developing the world's smallest and most flexible tinnitus aid that emits white noise through bone conduction technology. [ 29 ] [ 30 ] It is a patented medtech CE class IIa product [ 31 ] [ 32 ] with FDA 510(k) clearance in the U.S. [ 33 ] [ 34 ] It is a non-invasive device that attaches behind the ears and keeps ...
Solriamfetol is used to promote wakefulness in the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea in adults. [1] It appears to be more effective in improving excessive daytime sleepiness associated with obstructive sleep apnea than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant.
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