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The de novo protein synthesis theory of memory formation is a hypothesis about the formation of the physical correlates of memory in the brain. It is widely accepted that the physiological correlates for memories are stored at the synapse between various neurons .
Protein synthesis plays an important role in the formation of new memories. Studies have shown that protein synthesis inhibitors administered after learning, weaken memory, suggesting that protein synthesis is required for memory consolidation. Additionally, reports have suggested that the effects of protein synthesis inhibitors also inhibit ...
Specifically, it is unclear whether protein synthesis takes place in the postsynaptic cell body or in its dendrites. [39] Despite having observed ribosomes (the major components of the protein synthesis machinery) in dendrites as early as the 1960s, prevailing wisdom was that the cell body was the predominant site of protein synthesis in ...
By 2015 it had become clear that long-term memory requires gene transcription activation and de novo protein synthesis. [38] Long-term memory formation depends on both the activation of memory promoting genes and the inhibition of memory suppressor genes, and DNA methylation/DNA demethylation was found to be a major mechanism for achieving this ...
Internalization is dependent on protein synthesis, and p120 catenin proteins (p120ctn) are implicated in the turnover, degradation and ‘clustering’ of cadherins into the adhesive junctions at the synapse. [17] P120 ctn proteins are thought to either inhibit endocytosis of neural cadherins, or act at the cell surface to control cadherin ...
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...
It has been proposed that understanding the implications of the molecular, cellular and systemic mechanisms of these processes may elucidate how they are coordinated and integrated during memory formation. [3] For example, identifying the plasticity-related proteins (PRPs) involved in synaptic tagging and capture as well as the upstream and ...
These changes include new protein synthesis, the formation of new synaptic connections, and finally the activation of gene expression in accordance with the new neural configuration. [26] The encoding process has been found to be partially mediated by serotonergic interneurons, specifically in regard to sensitization as blocking these ...