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Intravenous sugar solution, also known as dextrose solution, is a mixture of dextrose (glucose) and water. [1] It is used to treat low blood sugar or water loss without electrolyte loss. [ 2 ] Water loss without electrolyte loss may occur in fever , hyperthyroidism , high blood calcium , or diabetes insipidus . [ 2 ]
Patients with extra-renal salt losses complicated by hyponatremia were found to be common-place, and consistent with McCance's description, they excreted urine virtually free of sodium. [22] In 1950, Sims et al, published their work that suggest observed relation between hyponatremia and pulmonary tuberculosis.
Therefore, significant hypernatremia should be treated carefully by a physician or other medical professional with experience in treatment of electrolyte imbalance. Specific treatments such as thiazide diuretics (e.g., chlorthalidone) in congestive heart failure or corticosteroids in nephropathy also can be used. [19]
Intravenous sugar solutions, such as those containing glucose (also called dextrose), have the advantage of providing some energy, and may thereby provide the entire or part of the energy component of parenteral nutrition. Types of glucose/dextrose include: D5W (5% dextrose in water), which consists of 278 mmol/L dextrose
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A 2004 statement by the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society (for children) uses slightly different cutoffs, where mild DKA is defined by pH 7.20–7.30 (bicarbonate 10–15 mmol/L), moderate DKA by pH 7.1–7.2 (bicarbonate 5–10) and severe DKA by pH<7.1 (bicarbonate below 5).
dextrose 5% in lactated Ringer's solution (intravenous sugar solution) D5NS dextrose 5% in normal saline (0.9%) (intravenous sugar solution) D5W, D 5 W dextrose 5% in water (intravenous sugar solution) D10W, D 10 W dextrose 10% in water (intravenous sugar solution) da da: give DAW dispense as written (i.e., no generic substitution)
Treatment includes administration of intravenous saline to rehydrate and 5% dextrose to turn off gluconeogenesis. Electrolyte imbalances, specifically hypokalaemia, should be corrected. Thiamine supplementation is often included to prevent Wernicke encephalopathy. Insulin is generally not used due to risk of hypoglycemia. [5]