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  2. Grapefruit juice - Wikipedia

    en.wikipedia.org/wiki/Grapefruit_juice

    Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]

  3. Grapefruit - Wikipedia

    en.wikipedia.org/wiki/Grapefruit

    Grapefruitdrug interactions are common, as the juice contains furanocoumarins that interfere with the metabolism of many drugs. This can prolong and intensify the effects of those drugs, leading to multiple side-effects such as abnormal heart rhythms, bleeding inside the stomach, low blood pressure, difficulty breathing, and dizziness.

  4. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruitdrug_interactions

    [19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...

  5. David Bailey (pharmacologist) - Wikipedia

    en.wikipedia.org/wiki/David_Bailey_(pharmacologist)

    Grapefruit decreased drug metabolism in humans, which likely represented the first clinical example of a food producing such an effect. Clinically, the concern is that a single judicious amount of grapefruit ingested even many hours beforehand would noticeably boost oral drug bioavailability and cause overdose toxicity.

  6. Naringenin - Wikipedia

    en.wikipedia.org/wiki/Naringenin

    Naringenin is a flavanone from the flavonoid group of polyphenols. [2] It is commonly found in citrus fruits, especially as the predominant flavonone in grapefruit. [2]The fate and biological functions of naringenin in vivo are unknown, remaining under preliminary research, as of 2024. [2]

  7. Grapefruit seed extract - Wikipedia

    en.wikipedia.org/wiki/Grapefruit_seed_extract

    Grapefruit seed extract (GSE), also known as citrus seed extract, is a liquid extract derived from the seeds, pulp, and white membranes of grapefruit. [1] GSE is prepared by grinding the grapefruit seed and juiceless pulp, then mixing with glycerin . [ 1 ]

  8. Naringin - Wikipedia

    en.wikipedia.org/wiki/Naringin

    Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (especially grapefruit) and other juices with medications is advised against. [7]

  9. Bergamottin - Wikipedia

    en.wikipedia.org/wiki/Bergamottin

    This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream. Under normal circumstances, the grapefruit juice effect is considered to be a negative interaction, and patients are often warned not to consume grapefruit or its juice when taking medication.