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This collection of cisternae is broken down into cis, medial, and trans compartments, making up two main networks: the cis Golgi network (CGN) and the trans Golgi network (TGN). The CGN is the first cisternal structure, and the TGN is the final, from which proteins are packaged into vesicles destined to lysosomes , secretory vesicles, or the ...
These different variations of Golgi cisternae are categorized into 3 groups; cis Golgi network, medial, and trans Golgi network. [2] The cis Golgi network is the first step in the cisternal structure of a protein being packaged, while the trans Golgi network is the last step in the cisternal structure when the vesicle is being transferred to ...
n/a Ensembl ENSG00000152291 n/a UniProt O43493 n/a RefSeq (mRNA) NM_006464 NM_001206840 NM_001206841 NM_001206844 NM_001368095 NM_001368096 n/a RefSeq (protein) NP_001193769 NP_001193770 NP_001193773 NP_006455 NP_001355024 NP_001355025 n/a Location (UCSC) Chr 2: 85.32 – 85.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Trans-Golgi network integral membrane protein 2 is a protein that ...
Trans-Golgi network vesicle protein 23 A (TVP23A) is a protein coded for the TVP23A gene, formerly known as FAM18A. [1]TVP23A is located on chromosome 16. [2] It is known to have human paralogs, TVP23B and TVP23C, as well as orthologs in many different species, notably yeast, mice, and chickens. [3]
MPRs are not found in the lysosomes; they cycle mainly between the trans-Golgi network and endosomes. The CI-MPR is also present on the cell surface. Around 10-20% of the CI-MPR can be found at the cell membrane. [14] Its function here is to capture any mannose 6-phosphate tagged enzymes that have accidentally entered the secretory pathway.
This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network.
Golgi complex RAB2A: ER, cis-Golgi network RAB2B: RAB3A: Secretory and synaptic vesicles RAB3B: RAB4A: Recycling endosomes RAB4B: RAB5A: Clathrin-coated vesicles, plasma membranes RAB5C (Vps21, RabB) Early endosomes RAB6A (Ypt6, RabC) Golgi and trans-Golgi network RAB6B: RAB6C: RAB6D: RAB7 (Ypt7, RabS) Late endosomes, vacuoles RAB8A ...
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated proteins have been linked to Alzheimer's and Parkinson's diseases.