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HER2 is found in a variety of tumours and some of these tumours carry point mutations in the sequence specifying the transmembrane domain of HER2. Substitution of a valine for a glutamic acid or a glutamine in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand.
[5] Description of a space station in Hermann Noordung's The Problem of Space Travel (1929). At the beginning of the 20th century, there was a burst of scientific investigation into interplanetary travel, inspired by fiction by writers such as Jules Verne ( From the Earth to the Moon , Around the Moon ) and H.G. Wells ( The First Men in the ...
The record for most time in space is held by Russian cosmonaut Oleg Kononenko, who has spent 1,111 days in space over five missions. He broke the record of Gennady Padalka on 4 February 2024 at 07:30:08 UTC during his fifth spaceflight aboard Soyuz MS-24 / 25 for a one year long-duration mission on the ISS . [ 21 ]
Das Problem der Befahrung des Weltraums – der Raketen-Motor (The Problem of Space Travel – The Rocket Motor) discusses space travel and its potential uses for scientific experiments. Germany Herman Potočnik: January 1933: British Interplanetary Society founded. UK Philip E. Cleator April 1933: First detection of radio waves from an ...
Countries represented only by suborbital space flyers are shaded. Note: citizens from the now-defunct East Germany, Czechoslovakia, and Soviet Union have also flown in space. Since the first human spaceflight by the Soviet Union, citizens of 48 countries have flown in space. For each nationality, the launch date of the first mission is listed.
Aldrin held that reusable spacecraft were the key in making space travel affordable, stating that the use of "passenger space travel is a huge potential market big enough to justify the creation of reusable launch vehicles". [76] Space tourism is a next step in the use of reusable vehicles in the commercialization of space.
Did not reach the Moon as intended, but discovered a second radiation belt around Earth. [2] 5.9 kg (13.0 lb) 1959 January 2 Soviet Union: Luna 1: Luna: Partial success: The first spacecraft to reach the vicinity of the Moon, and the first spacecraft to be placed in heliocentric orbit. 361 kg (794.2 lb) February 17 US: Vanguard 2E: Vanguard SLV ...
The International Map of the World (IMW; also the Millionth Map of the World, after its scale of 1:1 000 000) was a project to create a complete map of the world according to internationally agreed standards. It was first proposed by the German geographer Albrecht Penck in 1891. The Central Bureau of the Map of the World was established in London.