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Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Rosacea. What it looks like: Rosacea causes redness and thick skin on the face, usually clustered in the center.Easy flushing, a stinging sensation, and small, pus-filled pimples are other common ...
Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over a typical time course of weeks. [ 13 ] Cryotherapy is frequently used for few and well-defined lesions, [ 14 ] but undesired skin lightening, or hypopigmentation, may occur at the treatment site. [ 15 ]
Oral retinoids (e.g., acitretin, [4] [12] [13] etretinate [14]) may be helpful in treating arsenic-induced cutaneous lesions and in reducing the risk of cutaneous and internal malignancy formation, especially in Bowman's disease. Topical 5-fluorouracil cream [13] or 5% imiquimod cream [15] may be useful in treating arsenical keratoses and Bowen ...
If there is a persistent sore that does not heal or a growing lump within the rash, a skin biopsy should be performed to rule out the possibility of skin cancer. If the erythema ab igne lesions demonstrate pre-cancerous changes, the use of 5-fluorouracil cream has been recommended.
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Seborrheic dermatitis is a skin condition that causes inflamed, scaly patches of skin on the scalp and face, the American Academy of Dermatology explains. These patches are typically itchy, red ...