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Phineas P. Gage (1823–1860) was an American railroad construction foreman remembered for his improbable: 19 survival of an accident in which a large iron rod was driven completely through his head, destroying much of his brain's left frontal lobe, and for that injury's reported effects on his personality and behavior over the remaining 12 years of his life—effects sufficiently ...
John Martyn Harlow (1819–1907) was an American physician primarily remembered for his attendance on brain-injury survivor Phineas Gage, and for his published reports on Gage's accident and subsequent history. Boston Herald, May 20, 1907. Harlow was born in Whitehall, New York on November 25, 1819 to Ransom and Annis Martyn Harlow. [1]
Furthermore, in all animals, the nervous system is the organ of behavior. Therefore, every biological and behavioral variable that influences behavior must go through the nervous system to do so. Present-day research in behavioral neuroscience studies all biological variables which act through the nervous system and relate to behavior. [10]
The damage led Gage through a complete personality transformation that included the expression of socially inappropriate statements and lies towards his family and friends. Lesions in the right hemisphere's frontal lobe are associated with antisocial states [ 29 ] and left frontal lesions are associated with increase in violent behaviors.
[2] [3] Written for the layperson, Damásio uses the dramatic 1848 railroad accident case of Phineas Gage as a reference for incorporating data from multiple modern clinical cases, enumerating damaging cognitive effects when feelings and reasoning become anatomically decoupled. [3]
Some of the earliest thinking about possible biological bases of personality grew out of the case of Phineas Gage. In an 1848 accident, a large iron rod was driven through Gage's head, and his personality apparently changed as a result, although descriptions [44] of these psychological changes are usually exaggerated. [45] [46]
Fred "Rusty" Gage (born October 8, 1950) is an American geneticist known for his discovery of stem cells in the adult human brain. [1] Gage is a former president (2018–2023) of the Salk Institute for Biological Studies, [2] where he holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease and works in the Laboratory of Genetics.
Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, [1] with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural ...