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  2. Fluid deprivation test - Wikipedia

    en.wikipedia.org/wiki/Fluid_deprivation_test

    A fluid or water deprivation test is a medical test [1] which can be used to determine whether the patient has diabetes insipidus as opposed to other causes of polydipsia (a condition of excessive thirst that causes an excessive intake of water). The patient is required, for a prolonged period, to forgo intake of water completely, to determine ...

  3. Diabetes insipidus - Wikipedia

    en.wikipedia.org/wiki/Diabetes_insipidus

    Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst. [1] The amount of urine produced can be nearly 20 liters per day. [ 1 ] Reduction of fluid has little effect on the concentration of the urine. [ 1 ]

  4. Nephrogenic diabetes insipidus - Wikipedia

    en.wikipedia.org/wiki/Nephrogenic_diabetes_insipidus

    Persons with nephrogenic diabetes insipidus must consume enough fluids to equal the amount of urine produced. Any underlying cause such as high blood calcium must be corrected to treat nephrogenic diabetes insipidus. The first line of treatment is hydrochlorothiazide and amiloride. [10] Patients may also consider a low-salt and low-protein diet.

  5. Central diabetes insipidus - Wikipedia

    en.wikipedia.org/wiki/Central_diabetes_insipidus

    Because individuals with central diabetes insipidus are more likely than those with primary polyuria to have plasma sodium concentrations at the upper end of the normal reference range, measuring ambulatory plasma sodium concentration is beneficial. [8] The most often utilized test for diabetes insipidus is the water deprivation test (WDT).

  6. Chlortalidone - Wikipedia

    en.wikipedia.org/wiki/Chlortalidone

    Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. Nephrogenic diabetes insipidus occurs when the kidney is unable to concentrate urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate.

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    Lilly’s Zepbound, approved in November 2023 as the Indiana-based drug giant’s answer to Novo Nordisk’s Wegovy, showed 21% average weight loss after 72 weeks for its highest dose in its Phase ...

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