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ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). [5] [6] [7] HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family ...
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. In humans, the family includes Her1 (EGFR, ErbB1), Her2 , Her3 , and Her4 . The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are ...
Estrogen receptor (ER) (α, β) - binds and is activated by estrogens such as estradiol, estrone, and estriol; Progesterone receptor (PR) (A, B) - binds and is activated by progestogens such as progesterone; In addition, sex steroids have been found to bind and activate membrane steroid receptors, such as estradiol and GPER.
Breast cancer is the most common cancer in women worldwide, and can, rarely, also occur in men. ... the tumor cells do not have estrogen or progesterone receptors, and do not make a protein called ...
Estrogen receptors (ERs) are proteins found in cells that function as receptors for the hormone estrogen (17β-estradiol). [1] There are two main classes of ERs. The first includes the intracellular estrogen receptors, namely ERα and ERβ , which belong to the nuclear receptor family.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name triple-negative). [1]
The following is a list of hormones found in Humans. Spelling is not uniform for many hormones. Spelling is not uniform for many hormones. For example, current North American and international usage uses [ citation needed ] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier spelling ...
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