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White patches which have been present for a long period of time have a higher risk. [3] Persons with a positive family history of cancer in the mouth. [3] Candida infection in the presence of dysplasia has a small increased risk. [3] A change in the appearance of the white patch, apart from a change in the color, has a higher risk. [3]
Oral leukoplakia (white patch) on the left tongue. Proven to be severe dysplasia on biopsy Proven to be severe dysplasia on biopsy A premalignant (or precancerous) lesion is defined as "a benign, morphologically altered tissue that has a greater than normal risk of malignant transformation."
Transient lingual papillitis is generally diagnosed based on patient presentation, meaning where it is located in the mouth and how big the bump is. [8] The visual presentation can also accompany various signs and symptoms such as difficulty eating, having a "strawberry tongue", increased saliva production, and a burning or tingling sensation. [9]
Hairy leukoplakia is a white patch on the side of the tongue with a corrugated or hairy appearance. It is caused by Epstein-Barr virus (EBV) and occurs usually in persons who are immunocompromised, especially those with human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS).
Frictional keratosis: This typically presents as white plaques on the oral mucosa due to mechanical trauma. When the cause of frictional keratosis is removed the white patch may resolve. Hyperplastic reactive lesions or nodular swellings: These occur in the oral mucosa due to low grade inflammation or trauma. They develop where the mucosa is ...
Diagnosis is mainly clinical, based on the history and clinical appearance. The differential diagnosis includes other oral white lesions such as Leukoplakia, squamous cell carcinoma, oral candidiasis, lichen planus, white sponge nevus and contact stomatitis. [7] In contrast to pseudomembraneous candidiasis, this white patch cannot be wiped off. [7]
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The lesion may be rough or nodular in texture. [10] Hyperplastic candidiasis is uncommon, accounting for about 5% of oral candidiasis cases, [ 8 ] and is usually chronic and found in adults. The most common site of involvement is the commissural region of the buccal mucosa , usually on both sides of the mouth.